Antihyperglycemic Effect of Polyherbal Tea From Moringa oleifera, Cymbopogon citratus, and Stevia rebaudiana Leaves in Alloxan and HFD-Induced Mice (Mus musculus)

Abstrak

ABSTRACT
Diabetes Mellitus (DM) is a disease with metabolic disorders characterized by chronic
hyperglycemia and disorders of carbohydrate, fat, and protein metabolism due to insulin
secretion disorders. In general, DM patients require pharmacotherapy such as injected
insulin or oral antidiabetic drugs. Pharmacological treatment is relatively expensive and
needs to consider its efficacy and safety. Therefore, this study explores natural sources such
as medicinal plants. The aim of this study was to determine the antihyperglycemic effect of a
combination of boiled moringa leaves, lemongrass leaves and stevia leaves on mice (Mus
musculus) induced by alloxan. In this study, 25 mice were divided into 5 groups. The mice
will undergo adaptation for 7 days and then given HFD for 30 days. After 30 days, the mice
will be given alloxan 170 mg/kgBW for 3 days to induce DM. After DM was successfully
induced in mice, polyherbal tea combination of moringa leaves, lemongrass leaves and stevia
leaves was made and given, then continued with evaluation blood glucose, blood glucose
percentage, body weight, body weight percentage, index lee and liver organ index. The group
given herbal tea combination of moringa leaves (Moringa oleifera), lemongrass leaves
(Cymbopogon citratus) and stevia leaves (Stevia rebaudiana) with a concentration of 3.6
mg/mL showed a better decrease in KGD and %KGD compared to other treatment groups.
The decrease in BB, %BB and lee index was better in the group given a combination of
Moringa leaves (Moringa oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevia
leaves (Stevia rebaudiana) with a concentration of 7.2 mg/mL. The decrease in the liver
organ index was also better seen in the group given a combination of Moringa leaves
(Moringa oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevia leaves (Stevia
rebaudiana) with a concentration of 7.2 mg/mL. The group given herbal tea combination of
Moringa leaves (Moringa oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevia
leaves (Stevia rebaudiana) with a concentration of 3.6 mg/mL reduced BG and BG
percentage, while the group given herbal tea combination of Moringa leaves (Moringa
oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevia leaves (Stevia rebaudiana)
with a concentration of 7.2 mg/mL reduced BW, BW percentage, Lee index, and hait organ
index.
Keywords: Diabetes, Moringa Leaves, Lemongrass Leaves, Stevia Leaves, Blood Glucose
Levels, Body Weight